Scott J. Sherman, MD, PhD
Associate Professor of Neurology
Scott J. Sherman, MD, PhD, is Associate Professor of Neurology at the University of Arizona College of Medicine at the Arizona Health Sciences Center in Tucson, Medical Director of the Arizona Chapter of the American Parkinson's Disease Association, and Director of the Parkinson's Disease Program of the Rehabilitation Institute of Tucson.
Dr Sherman received a medical degree and a doctorate in pharmacology from the University of Washington in Seattle. He completed an anesthesiology residency at the University of Washington and a neurology residency and epilepsy fellowship training at the University of Arizona College of Medicine.
Dr Sherman's areas of research interest include deep brain stimulation, gene therapy, and cell-based therapy for Parkinson disease. He is an investigator for two multicenter studies, one evaluating the use of SPECT scanning for early diagnosis of Parkinson's disease and another evaluating a novel class of drugs for treatment of advanced motor fluctuations in Parkinson's disease.
Dr Sherman's original articles and abstracts on understanding and treating parkinsonism have been published or accepted for publication by Science, Movement Disorders, Parkinsonism and Related Disorders, Neuroscience, and many other journals. He lectures before Parkinson disease support groups and other public meetings and has been invited to lecture to the medical community about new therapies for and patient care issues with Parkinson disease and movement disorders.
He holds memberships in the Movement Disorder Society, the American Epilepsy Society, and the American Academy of Neurology. He has been awarded for outstanding achievement in teaching and outstanding progress in research by the University of Arizona College of Medicine.
Education/Training:
BS: Brandeis University, 1978
MD: University of Washington, 1985
PhD: University of Washington, 1985
Internship: University of Washington, 1985-86
Residency (Anesthesiology): University of Washington, 1987-90
Residency (Neurology): University of Arizona, 1993-96
Fellowship (Epilepsy): University of Arizona, 1996-97
Clinical/Research Interests:
Movement Disorders; cell-based and gene-based strategies for the treatment of Parkinson's disease.
Selected Publications:
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Falk T, Strazdas L, Borders R, Kilani RK, Yool AJ, and Sherman SJ.
A herpes simplex viral vector expressing green fluorescent protein can
be used to visualize morphological changes in high-density neuronal culture.
EJB Electronic Journal of Biotechnology [Online] Vol. 4 (1) April 15, 2001
Available from
http://ejb.ucv.cl/content/vol4/issue1/full/5/index.html.
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Farley BG, Sherman S, Koshland GF. Shoulder muscle activity during
multijoint movement in Parkinson's disease across a range of speeds.
Experimental Brain Research, 2003, 154:160-75.
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Falk T, Kilani RK, Borders RS, Strazdas LA, Steidl JV, Yool AJ and
Sherman SJ. Developmental regulation of the A-type potassium-channel
current in hippocampal neurons: Role of the Kvbeta1.1 subunit.
Neuroscience. 2003, 120(2):387-404.
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Falk T, Zhang S, Erbe E, Sherman SJ. Neurochemical and electrophysiological
characteristics of rat striatal neurons in primary culture. Journal
Comparative Neurology 2006, 494:275-289.
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McKay B, Goodman B, Falk T, Sherman S. Retinal pigment epithelial
cell transplantation could provide trophic support in Parkinson's disease:
results from an in vitro model system. Journal Experimental Neurology
2006, 201:234-43.
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Frank M, Scheres A, Sherman S. Understanding decision-making deficits
in neurological conditions: insights from models of natural action
selection. Philosophical Transactions Royal Society London Biological
Sciences 2007, 362:1641-1654.
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Frank M, Samanta J, Moustafa A, Sherman S. Hold your horses: Impulsivity,
deep brain stimulation, and medication in Parkinsonism. Science 2007,
318:1309-1312.
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Ahmed N, Sherman S, VanWyck D. Frailty in Parkinson's disease and its
clinical implications. Parkinsonism Related Disorders, 2008,
14(4):334-37.
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Ciucci M, Barkmeier-Kraemer J, Sherman S. Subthalamic nucleus deep brain
stimulation improves deglutition in Parkinson's disease. Movement
Disorders 2008, 23(5):676-83.
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Falk T, Xie J, Zhang S, Kennedy J, Yool A., Sherman S. Over-expression
of the potassium channel Kir2.3 by an adenoviral vector using the
dopamine-1 receptor promoter selectively inhibits striatal neurons.
Neuroscience 2008, 155(1):114-127.
- Moustafa AA, Sherman S, Frank M. A dopaminergic basis for working
memory, learning and attentional shifting in Parkinsonism.
Neuropsychologia 2008, 46:3144-3156.
- Moustafa AA, Cohen M, Sherman S, Frank M. A role for dopamine in
temporal decision making and reward maximization in Parkinsonism. Journal
of Neuroscience 2008, 28:122294-304.
