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Department of Neurology - Faculty

Dr. Miguel Estevez , MD, PhD Miguel Estevez , MD, PhD
Assistant Professor of Clinical Neurology

CURRICULUM VITAE

Education:
1982-87 B.S., Georgia Tech, Atlanta, GA (Applied Biology)
1987-92 Ph.D., University of Missouri, Columbia MO (Biological Sciences/Molecular Biology (Advisor, Donald Riddle, Ph.D.)
1993-97 M.D., University of Missouri School of Medicine, Columbia, MO
Postgraduate Training:
1992-93 Postdoctoral Fellow, Biological Sciences, (Developmental Biology), University of Missouri, Columbia, MO (Donald Riddle, Ph.D.)
1997-98 Medical Intern, Department of Internal Medicine, University of Internal Medicine, Missouri Medical Center, Columbia, MO (John Yanos, MD)
1998-2001 Resident, Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA (Mark Scheur, MD)
Licensure and Certification:
2001- Pennsylvania (#MD-072669L)
2005 Board-Certified in Neurology, American Board of Psychiatry and Neurology
2009- Arizona (41329)
Academic Appointments:
2001-02 Instructor, Neurology, University of Pittsburgh Medical Center
2005- Assistant Professor, Neurology, University of Pittsburgh School of Medicine
2009 Assistant Professor, Department of Neurology, University of Arizona College of Medicine, Tucson AZ
Hospital Appointments:
2002-2009 Staff Physician, Research Division and Department of Neurology, Pittsburgh Veteran's Administration Medical Center
2009- Staff Physician, Department of Neurology, University Physicians Healthcare at Kino Community Hospital, Tucson AZ
Professional Societies:
Genetics Society of America
Society for Neuroscience
American Academy of Neurology
National Headache Foundation
Awards and Honors:
1987-92 Fellow, Molecular Biology Program, University of Missouri, Columbia, Missouri
1989 Scholarship, Embryology Course, Marine Biological Laboratory, Woods Hole, MA
1989-92 Individual Predoctoral Award, National Science Foundation
2000-01 Chief Resident, Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA
2001-06 Burroughs-Wellcome Career Development Award
2002-05 Veterans Administration Career Development Award
Manuscript Reviewer:
Journal of Neuroscience Research
Journal of the Neurological Sciences
In-Service Teaching:
09/10/09 Neurology Department Clerkship Seminar, Department of Neurology, UA COM
09/16/09 Neurology Department Grand Rounds, Modeling of Channelopathy-related Neurodegeneration in Worms and Mice UA COM
12/03/09 Headache Lecture to Medical Students, Department of Neurology, UA COM
Invited Lectures:
2004 Speaker, Senior Vice Chancellor Seminar Series, University of Pittsburgh: Migraine-related effects of P/Q Channel function in C. elegans.
2007 Guest Speaker, University of Toronto, Samuel Lunenfeld Research Institute
2009 Guest Speaker, Neuraxon Headache Minisymposium, Tucson AZ
03/10 Guest Speaker "The Molecular Basis of ALS", 21st Annual Spring Brain Conference, Omni Tucson Resort, Tuscon AZ
Citizenship (Intramural):
2001-03 Neurology Resident Applicant Screening Committee Member, University of Pittsburgh Medical Center, Pittsburgh, PA
Citizenship (Extramural):
2004 NIH Consensus Panel Member: Advances in Prevention and Management of Migraine Headaches. Identifying Target Genes for Therapy Development
2006- Chairman, Veterans Administration, Institutional Biosafety Committee

TEACHING

2000-01 Assistant, MS2 Clinical Skills Course, University of Pittsburgh School of Medicine
2004- Facilitator, MS2 Neuroscience Course, University of Pittsburgh School of Medicine
2006- Facilitator, MS2 Integrated Case Studies Course, University of Pittsburgh School of Medicine
Graduate Student Advisor:
2004-2008 Kathleen Morgan, PhD. Candidate in Interdisciplinary Program in the Biomedical Sciences. Graduated with Ph.D.
Graduate Student Dissertation Thesis Committees:
2004- Jerrod Poe, PhD. Candidate in Interdisciplinary Program in the Biomedical Sciences
2006-07 Katherine Demachio, PhD. Candidate in Biological Sciences
Postdoctoral Trainees:
2003-2005 Rakesh Pandey, PhD. (Lucknow University), Postdoctoral Fellow, Current Position: Section Leader, Central Institute of Medicinal and Aromatic Plants, Lucknow, India
2005-2008 Michelle Jones, PhD (University of Chicago), Postdoctoral Fellow, Current Position: Research and Development, Immunetrics, Inc., Pittsburgh, PA
Graduate Student Mentoring:
2004 Mentor, Laboratory Rotation, Jerrod Poe, PhD Candidate in Interdisciplinary Studies, University of Pittsburgh School of Medicine
2007 Mentor, Laboratory Rotation, Seyeda Ahmad, PhD Candidate in Interdisciplinary Program in the Biomedical Sciences, University of Pittsburgh School of Medicine
2007 Comprehensive Exam Committee Member, Olivia Long, PhD. Candidate in Interdisciplinary Program in the Biomedical Sciences, University of Pittsburgh School of Medicine
Medical Student Mentoring:
2004-05 Clinical Mentor, David Nauen, MD,PhD Candidate, University of Pittsburgh School of Medicine
Undergraduate Student Mentoring:
2007-08 Mentor, Undergraduate Research, Gino Inverso, BS Candidate in Biological Sciences

PUBLICATIONS

Peer-Reviewed Publications:

  1. Politz SM, Philipp M, Estevez M., O'Brien PJ, Chin KJ. (1990). Genes that can be mutated to reveal hidden antigenic determinants in the cuticle of the nematode C. elegans. PNAS 87(8):2901-2905.
  2. Estevez M, Attisano L, Wrana JL, Albert PS, Massagué J, Riddle DL.(1993). The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development. Nature 365: 644-649.
  3. ten Dijke P., Yamashita H., Sampath T.K., Reddi A.H., Estevez M., Riddle D.L., Ichijo H., Heldin C.H., Miyazono K. Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4. J Biol Chem. (1994). Jun 24;269(25):16985-8.
  4. Estevez, M., Chu, C., Pless, M. (2002). Small B-cell lymphoma presenting with dural thickening and cranial neuropathies. Journal of Neuro-oncology 59:243-247.
  5. Estevez, M., Estevez, A., Cowie, R.H., Gardner, K.L. (2004). The voltage-gated calcium channel UNC-2 is involved in stress-mediated regulation of tryptophan hydroxylase. J Neurochem. Jan; 88(1):102-13.
  6. Estevez, A., Harper-Cowie, R.H., Gardner, K.L., Estevez, M. (2006). Both insulin and calcium channel signaling are required for developmental regulation of serotonin synthesis in the chemosensory ADF neurons of Caenorhabditis elegans. Dev. Biol. 298(1):32-44.
  7. Zubenko, G.S., Jones, M.L., Estevez, A.O., Hughes III, H. B., Estevez, M. (2009).Genetic Dissection of a Complex Behavior in Caenorhabditis elegans: CREB Regulation of foraging through Serotonergic ADF Neurons. American Journal of Medical Genetics. Am J Med Genet B Neuropsychiatr Genet. Jan 5;150B(1):12-23.

Review Articles:

  1. Estevez, M., Gardner, K.L. (2004). Update on migraine genetics. Hum. Gen. Feb;114(3):225-235.
  2. Estevez M. Invertebrate modeling of a migraine channelopathy. Headache. 2006 Jun;46 Suppl 1:S25-31.

Book Chapters:

  1. Estevez, M., and Riddle, D.L. (1995). The Protein Kinase Facts Book. "Receptor Protein-Serine Kinases", New York, Academic Press. Ed. Hardie, G., and Hanks, S

Peer-Reviewed Abstracts

  1. Estevez, A., Estevez, M., Cowie, R.H. (2003).The insulin pathway acts to positively regulate tryptophan hydroxylase expression. International Caenorhabditis elegans Meeting. Session on Pathology. UCLA. Los Angeles, CA. June 3-4.
  2. Estevez, M., Estevez, A., Cowie, R.H. (2003). The voltage-gated calcium channel UNC-2 is involved in regulation of tryptophan hydroxylase. International Caenorhabditis elegans Meeting. Session on Pathology. UCLA. Los Angeles, CA. June 3-4.
  3. Estevez, A., Estevez M. (2005). Identification of downstream regulators of serotonin synthesis in ADF. Session on Neurodegeneration. UCLA. June 25-29.
  4. Pandey, R. Estevez, A.O., Estevez, M. (2005). Thermally-induced tremor/convulsions in Caenorhabditis elegans can be suppressed by human anti-epileptic agents. Session on Neurodegeneration. UCLA. June 25-29.
  5. Morgan K.L., Cowie R.H., Estevez, A., Estevez M. (2005). Developing a model of Amyotrophic Lateral Sclerosis (ALS) using Selenium toxicity in C. elegans. Session on Neurodegeneration. UCLA. June 25-29.
  6. Morgan K.L., Robin H. Cowie, Estevez, A., Estevez M. (2005). Developing a model of Sporadic ALS using Selenium toxicity in Caenorhabditis elegans. Neuroscience 2005. 35th annual meeting of the Society for Neuroscience. Session on Neurodegeneration. Washington, DC. November 12-16.
  7. Jones, M., Estevez, A.O., and Estevez, M. (2006). Abstract: The serotonin receptor SER-4 is involved in feedback regulation of serotonin synthesis. 1st C. elegans Neuronal Development Meeting, Madison, WI, July 9-12.
  8. Estevez, A.O. and Estevez, M. (2006). Abstract: Understanding the role of calcium channel signaling in a worm model of migraine creates a "headache" on its own. 1st C. elegans Neuronal Development Meeting, Madison, WI, July 9-12.
  9. Morgan, K., Estevez A.O., Estevez, M. (2007). Abstract: Modeling environmentally-induced sporadic ALS. International Caenorhabditis elegans Meeting. Session on Pathology. UCLA. Los Angeles, CA. June 27-July 1st.
  10. Jones, M., Estevez, A.O., and Estevez, M. (2007). Abstract: Regulation of dopamine receptor expression by serotonin receptor antagonists. International Caenorhabditis elegans Meeting. Session on Pathology. UCLA. Los Angeles, CA. June 27-July 1st.
  11. Estevez, A.O. and Estevez, M. (2007). Abstract: UNC-2-dependent changes in tryptophan hydroxylase expression are c

Broadcast and Print Media:

  1. 2002- Informational interviews with PBS, Pittsburgh Tribune-Review, Pitt Medonserved in the mouse. International Caenorhabditis elegans Meeting. Session on Pathology. UCLA. Los Angeles, CA. June 27-July 1st.

Updated: 06/01/2010